Lost was a television show which aired on ABC between November 22, 2004 and May 23, 2010. It starred Greg Grunberg and a bunch of other, less-important people. In the show, Greg's character was Seth Norris, the pilot of Oceanic 815 en route from Sydney to Los Angeles. Through his expertise, he managed to impossibly crash the broken-up plane onto an island, allowing nearly 80 survivors.
The story is told through a series of flashbacks, flash-forwards, and flash-sideways. It makes about as much sense as the previous sentence.
See Universe X for what this is all leading up to.