Skittles came to prominence during the Toobin' with the Devil episode of NSFW. Justin wanted to play an NSFW Skittles commercial for the opening video, but because of its inappropriate content they decided to have Iyaz watch it and everyone else watched his reaction.
By the end of the episode, viewers had created multiple Adobeshops involving Skittles and Justin's frozen face.
Taste the rainbow.
(This is not safe for work and not an actual Skittles commercial.)